I started working to create some fun tables for Arcane Afflictions for Dungeons and Dragons 5th Edition. Lots of these inspirations from the roguelike game Dungeon Crawl Stone Soup‘s mutations. In addition there are some inspired by the bad things that happen to people in the show Fringe. Rather than just give a list of fluff I tried to develop some mechanical reinforcement of the affliction itself. Keep in mind these are NOT necessarily balanced in the numeric sense and if they were its for low level adventuring (around 1-3.) And when the list refers to a saving throw assume the DC is something like 10-15 or whatever you decide.
The Arcane Afflictions Table